Tesamorelin

Choosing a supplier for Tesamorelin research comes down to reproducibility: the same sequence, the same purity profile and the same handling documentation on every order. Protide Health Lab provides Tesamorelin as a sterile-filtered lyophilised powder in sealed vials, each supported by a third-party HPLC-MS purity report and a certificate of analysis that is tied to the specific batch you receive.

Tesamorelin is a synthetic 44-amino-acid analogue of growth hormone-releasing hormone, matching the full length of the natural hormone but with a trans-3-hexenoyl modification on the tyrosine residue at position 1. That modification is designed to slow cleavage by DPP-IV and thereby extend the peptide’s activity relative to native GHRH. Lyophilisation extends shelf life and reduces the risk of hydrolysis during transit, which is why essentially all research peptides are distributed as a dry powder rather than as a pre-dissolved solution.

Tesamorelin Key Takeaways

• Compound class: synthetic 44-amino-acid GHRH analogue.
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 10mg, 20mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price range: $70 to $140 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is Tesamorelin?
2. Tesamorelin Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order Tesamorelin Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is Tesamorelin?

You can obtain Tesamorelin from Protide Health Lab as a synthetic 44-amino-acid GHRH analogue supplied in a sealed, batch-labelled vial. Each vial carries a certificate of analysis from an independent laboratory, and the material is screened for identity by mass spectrometry and for purity by high-performance liquid chromatography before it is released for sale.

Also known as: Tesamorelin, TH9507, GHRH 1-44 analogue, trans-3-hexenoyl GHRH.

Protide Health Lab publishes the analytical result rather than an efficacy claim. Before you design a study around Tesamorelin, review the certificate of analysis for the batch in question and confirm that the reported purity and the identity confirmation meet the acceptance criteria your protocol requires.

Tesamorelin Specifications

Property	Details
Product Contents	Tesamorelin Lyophilized Powder (99% purity) in 3mL vial.
Available Sizes	10mg, 20mg
Peptide Type	Synthetic 44-amino acid analog
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 221 H 366 N 72 O 67 S
Molecular Weight	5135.91 g/mol
Sequence	(trans-3-hexenoic acid)-YADAIFTNSY RKVLGQLSAR KLLQDIMSR QQGESNQERG ARARL-NH 2
CAS Number	218949-48-5
CID	16137828
Appearance	White to off-white lyophilized powder
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water

These parameters describe the compound as it is released from storage. Where two different values appear for the same property – as with multi-component blends – the individual values apply to each constituent peptide, and the total vial content is given under available sizes.

Research Overview: GHRH receptor and cAMP signalling

Tesamorelin appears in the scientific literature as a synthetic 44-amino-acid GHRH analogue used in controlled laboratory investigation. The summaries below are drawn from published research and describe areas of study rather than any approved or intended use. When researchers search for buy tesamorelin online, the practical comparison points are the analytical method used, the batch number behind the certificate of analysis and the storage history of the vial, not the marketing copy.

GHRH receptor and cAMP signalling

Research interest in GHRH receptor and cAMP signalling centres on how Tesamorelin behaves at the level of cell-migration, proliferation and viability measurements. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Growth hormone pulsatility research

Within Growth hormone pulsatility research, investigators use Tesamorelin to probe signalling cross-talk between converging pathways. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

IGF-1 axis endpoints

Studies grouped under IGF-1 axis endpoints generally treat Tesamorelin as a tool for examining dose-dependent changes in cellular readouts. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Visceral adipose and metabolic models

In Visceral adipose and metabolic models, published work typically examines Tesamorelin from the perspective of receptor occupancy and downstream second-messenger activity. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

DPP-IV stability studies

Research interest in DPP-IV stability studies centres on how Tesamorelin behaves at the level of gene-expression shifts and protein-level endpoints. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Hypothalamic-pituitary axis research

Within Hypothalamic-pituitary axis research, investigators use Tesamorelin to probe enzyme kinetics and substrate handling. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Reported Mechanism of Action

Tesamorelin acts at pituitary GHRH receptors and drives the Gs/cAMP/protein-kinase-A cascade that governs growth hormone synthesis and release. Because GHRH signalling in somatotropic cells is pulsatile and coupled to the endogenous secretory rhythm, research on this analogue focuses on release dynamics, downstream IGF-1 responses and the visceral adipose endpoints that have been linked in published literature to the GH/IGF-1 axis.

Because Tesamorelin is studied as a synthetic 44-amino-acid GHRH analogue, reported mechanisms are generally described at the level of receptor engagement, second-messenger generation and downstream gene or enzyme activity. Reproducing any of those observations depends on using material whose identity and purity have been independently confirmed.

Purity, Testing and Certificates of Analysis

Purity is the single most important variable in peptide research because impurities change the effective concentration of the active sequence and can introduce confounding biological activity. Batch documentation includes the HPLC chromatogram, the mass spectrometry identity confirmation and the reported purity percentage, all of which can be archived alongside your experimental records.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Lyophilised material is best held at -20 degrees Celsius away from direct light; avoid repeated temperature cycling by keeping only the working aliquot at hand. Once reconstituted, the solution should be refrigerated at 2 to 8 degrees Celsius and used within a defined working window rather than stored indefinitely.

Reconstitution

Bacteriostatic water is the usual starting diluent, and a preserved 0.9% benzyl alcohol solution is a practical alternative when the same vial will be accessed more than once.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 10mg vial dissolved in 2 mL of diluent gives approximately 5 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle Tesamorelin in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

Vial size	Price	Availability
10mg	$70	In stock
20mg	$140	In stock

Larger vial sizes are intended for laboratories that prepare working stocks in bulk or that run long series of repeat experiments, since a single larger vial reduces the number of separate preparations and therefore the batch-to-batch variability introduced by handling. Smaller vials are generally the better choice for dose-ranging studies where several concentrations are compared side by side.

How to Order Tesamorelin Online

Each order ships from domestic inventory with tracking information and the corresponding batch certificate of analysis, so documentation arrives with the material. Browse the full Peptides category listing, or compare other compounds in the same family: Sermorelin, CJC-1295 (No-DAC) 10mg, Tesamorelin & Ipamorelin Blend.

Protide Health Lab supplies Tesamorelin from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is Tesamorelin?

Tesamorelin is a synthetic 44-amino-acid analogue of growth hormone-releasing hormone, matching the full length of the natural hormone but with a trans-3-hexenoyl modification on the tyrosine residue at position 1 It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is Tesamorelin supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of Tesamorelin are available?

Tesamorelin is offered in 2 configurations: 10mg, 20mg. The larger sizes suit repeat runs that benefit from a single stock preparation, while smaller vials keep unused material in the stable lyophilised state for longer.

How much does Tesamorelin cost?

Pricing runs from $70 to $140 per vial depending on the size selected, and the current price for each configuration is listed in the sizes and pricing table above. The certificate of analysis is included at no additional cost.

What is Tesamorelin supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should Tesamorelin be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute Tesamorelin?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is Tesamorelin intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

The following compounds are commonly ordered alongside Tesamorelin – either because they act on related pathways or because they belong to the same structural family.

• Sermorelin – synthetic 29-amino-acid GHRH(1-29) amide.
• CJC-1295 (No-DAC) 10mg – synthetic 29-amino-acid growth hormone-releasing hormone analogue.
• Tesamorelin & Ipamorelin Blend – dual-peptide blend of tesamorelin and ipamorelin.
• Tesamorelin, Ipamorelin & CJC-1295 (No DAC) Blend 12mg – triple-peptide secretagogue blend (tesamorelin, ipamorelin, CJC-1295 No DAC).

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 18840302)
• Peer-reviewed literature indexed in PubMed (PMID 28525098)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.