Melanotan-1 10mg

Choosing a supplier for Melanotan-1 10mg research comes down to reproducibility: the same sequence, the same purity profile and the same handling documentation on every order. The Melanotan-1 10mg offered here is a lyophilised research powder, tested by an independent laboratory using HPLC-MS and released with a batch-matched purity report, so the analytical data you review belongs to the material in your vial.

Melanotan-1 is a synthetic tridecapeptide analogue of alpha-melanocyte-stimulating hormone. It carries two substitutions – Nle4 and D-Phe7 – that make it both more potent and markedly more resistant to enzymatic degradation than the native hormone, which is why it became the prototype for melanocortin receptor research in pigmentation biology. Because the lyophilised format removes water from the preparation, the powder is stable during transport and can be stored frozen for extended periods before it is reconstituted for experimental work.

Melanotan-1 10mg Key Takeaways

• Compound class: synthetic tridecapeptide alpha-MSH analogue.
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 10mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price: $50 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is Melanotan-1 10mg?
2. Melanotan-1 10mg Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order Melanotan-1 10mg Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is Melanotan-1 10mg?

Melanotan-1 10mg is one of the synthetic tridecapeptide alpha-MSH analogue entries in the Protide Health Lab research catalogue. It is released for sale only after independent identity confirmation by mass spectrometry and purity measurement by HPLC, and the resulting report is stored against the batch number printed on the vial.

Also known as: Melanotan-1, MT-1, Afamelanotide, alpha-MSH analogue, Nle4-D-Phe7-alpha-MSH.

Nothing in this catalogue is presented as a treatment or a supplement. What the documentation does establish is that Melanotan-1 10mg is the sequence it claims to be, at the purity reported, in the vial that was shipped to you – which is the part of a peptide purchase that can actually be verified.

Melanotan-1 10mg Specifications

Property	Details
Product Contents	Melanotan-1 10mg Lyophilized Powder in 3mL vial.
Available Sizes	10mg
Peptide Type	Synthetic tridecapeptide (alpha-MSH analog sequence)
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 78 H 111 N 21 O 19
Molecular Weight	1,646.87 g/mol
Sequence	Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH 2
CAS Number	75921-69-6
CID	16197727
Appearance	White to off-white lyophilized powder
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water

Reference values are provided for laboratory identification and comparison purposes. Where a molecular formula, sequence or identifier is listed, it reflects the compound as it is supplied and should be cross-checked against your own internal specification before use.

Research Overview: Melanocortin receptor (MC1R) signalling

Published investigation of Melanotan-1 10mg treats it as a synthetic tridecapeptide alpha-MSH analogue and concentrates on mechanistic questions rather than clinical outcomes. The sections that follow summarise those areas so that a researcher can see where the compound has been studied. For anyone looking to buy melanotan 1 online, Protide Health Lab keeps the decision simple by attaching the analytical record for the specific batch to the product page and to the shipment.

Melanocortin receptor (MC1R) signalling

Research interest in Melanocortin receptor (MC1R) signalling centres on how Melanotan-1 10mg behaves at the level of gene-expression shifts and protein-level endpoints. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Melanogenesis and tyrosinase expression

Within Melanogenesis and tyrosinase expression, investigators use Melanotan-1 10mg to probe enzyme kinetics and substrate handling. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Pigmentation biology and photoprotection

Studies grouped under Pigmentation biology and photoprotection generally treat Melanotan-1 10mg as a tool for examining cell-migration, proliferation and viability measurements. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

cAMP/PKA pathway research

In cAMP/PKA pathway research, published work typically examines Melanotan-1 10mg from the perspective of signalling cross-talk between converging pathways. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Peptide stability and analogue pharmacology

Research interest in Peptide stability and analogue pharmacology centres on how Melanotan-1 10mg behaves at the level of dose-dependent changes in cellular readouts. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Melanocyte culture models

Within Melanocyte culture models, investigators use Melanotan-1 10mg to probe receptor occupancy and downstream second-messenger activity. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Reported Mechanism of Action

Melanotan-1 acts as an agonist at melanocortin-1 receptors (MC1R) on cutaneous melanocytes, activating the cAMP/PKA pathway that drives tyrosinase expression and melanin synthesis. Because the melanocortin receptor family also includes MC3R, MC4R and MC5R, the analogue appears in studies of pigmentation control, photoprotection and, at higher doses, of central melanocortin signalling.

It is worth noting that mechanistic reports on Melanotan-1 10mg come from several different model systems – cultured cells, tissue preparations and animal models – and that conclusions drawn in one system are not automatically transferable to another. The synthetic tridecapeptide alpha-MSH analogue classification describes the chemistry of the material, not a validated clinical action.

Purity, Testing and Certificates of Analysis

In peptide work, an impurity is not just a purity number on a page: co-eluting sequences, residual trifluoroacetate and moisture all alter how a preparation behaves in culture or in an assay. The certificate of analysis records the method used, the retention profile, the observed mass and the final purity figure, giving you a verifiable record rather than an unqualified purity claim.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Unreconstituted lyophilised powder should be stored at -20 degrees Celsius, protected from light and kept as dry as possible. After dissolution, store the preparation refrigerated at 2 to 8 degrees Celsius and aliquot it so that freeze-thaw cycling is avoided.

Reconstitution

For dissolution, start with bacteriostatic water. If the peptide is slow to enter solution, a preserved 0.9% benzyl alcohol solution can be used in its place.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 10mg vial dissolved in 2 mL of diluent gives approximately 5 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle Melanotan-1 10mg in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

Melanotan-1 10mg is supplied as a single 10mg vial priced at $50.

The vial range reflects the two common research patterns: small vials for titration and pilot work where only a little material is consumed per experiment, and larger vials for repeated runs that benefit from a single, internally consistent stock preparation.

How to Order Melanotan-1 10mg Online

Orders placed before the daily cut-off are packed the same working day, and every shipment includes the batch-matched certificate of analysis. Browse the full Peptides > Melanotan Peptides category listing, or compare other compounds in the same family: Melanotan-2 (MT-2) 10mg, PT-141 10mg, KPV 10mg.

Protide Health Lab supplies Melanotan-1 10mg from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is Melanotan-1 10mg?

Melanotan-1 is a synthetic tridecapeptide analogue of alpha-melanocyte-stimulating hormone It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is Melanotan-1 10mg supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of Melanotan-1 10mg are available?

Melanotan-1 10mg is supplied as a single 10mg vial.

How much does Melanotan-1 10mg cost?

Melanotan-1 10mg is priced at $50 per vial, and the batch certificate of analysis is included with the order.

What is Melanotan-1 10mg supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should Melanotan-1 10mg be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute Melanotan-1 10mg?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is Melanotan-1 10mg intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

If your study design calls for more than one compound, these related products are the ones most often purchased together with Melanotan-1 10mg.

• Melanotan-2 (MT-2) 10mg – synthetic cyclic heptapeptide alpha-MSH analogue.
• PT-141 10mg – synthetic cyclic heptapeptide melanocortin receptor agonist.
• KPV 10mg – synthetic tripeptide (Lys-Pro-Val), C-terminal fragment of alpha-MSH.
• VIP 10mg – endogenous 28-amino-acid neuropeptide (vasoactive intestinal peptide).

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 11134297)
• Peer-reviewed literature indexed in PubMed (PMID 11368042)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.