PT-141 10mg

Choosing a supplier for PT-141 10mg research comes down to reproducibility: the same sequence, the same purity profile and the same handling documentation on every order. The PT-141 10mg offered here is a lyophilised research powder, tested by an independent laboratory using HPLC-MS and released with a batch-matched purity report, so the analytical data you review belongs to the material in your vial.

PT-141 – bremelanotide – is a cyclic heptapeptide melanocortin receptor agonist related in structure to Melanotan-2. It was developed specifically to exploit central melanocortin signalling, and most published research on it concerns MC4R-mediated effects in the central nervous system rather than peripheral pigmentation. Because the lyophilised format removes water from the preparation, the powder is stable during transport and can be stored frozen for extended periods before it is reconstituted for experimental work.

PT-141 10mg Key Takeaways

• Compound class: synthetic cyclic heptapeptide melanocortin receptor agonist.
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 10mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price: $55 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is PT-141 10mg?
2. PT-141 10mg Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order PT-141 10mg Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is PT-141 10mg?

PT-141 10mg is one of the synthetic cyclic heptapeptide melanocortin receptor agonist entries in the Protide Health Lab research catalogue. It is released for sale only after independent identity confirmation by mass spectrometry and purity measurement by HPLC, and the resulting report is stored against the batch number printed on the vial.

Also known as: PT-141, Bremelanotide, melanocortin agonist peptide, MC4R agonist heptapeptide.

Nothing in this catalogue is presented as a treatment or a supplement. What the documentation does establish is that PT-141 10mg is the sequence it claims to be, at the purity reported, in the vial that was shipped to you – which is the part of a peptide purchase that can actually be verified.

PT-141 10mg Specifications

Property	Details
Product Contents	PT-141 10mg Lyophilized Powder (99% purity) in 3mL vial.
Available Sizes	10mg
Peptide Type	Synthetic cyclic heptapeptide melanocortin receptor agonist (alpha-MSH analog)
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 50 H 68 N 14 O 10
Molecular Weight	1,025.18 g/mol
Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
CAS Number	189691-06-3
CID	9941379
Appearance	White to off-white lyophilized powder
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water and DMSO

Reference values are provided for laboratory identification and comparison purposes. Where a molecular formula, sequence or identifier is listed, it reflects the compound as it is supplied and should be cross-checked against your own internal specification before use.

Research Overview: Central melanocortin (MC4R) signalling

Published investigation of PT-141 10mg treats it as a synthetic cyclic heptapeptide melanocortin receptor agonist and concentrates on mechanistic questions rather than clinical outcomes. The sections that follow summarise those areas so that a researcher can see where the compound has been studied. For anyone looking to buy pt 141 online, Protide Health Lab keeps the decision simple by attaching the analytical record for the specific batch to the product page and to the shipment.

Central melanocortin (MC4R) signalling

Studies grouped under Central melanocortin (MC4R) signalling generally treat PT-141 10mg as a tool for examining gene-expression shifts and protein-level endpoints. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Cyclic peptide pharmacology

In Cyclic peptide pharmacology, published work typically examines PT-141 10mg from the perspective of enzyme kinetics and substrate handling. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Appetite and autonomic regulation research

Research interest in Appetite and autonomic regulation research centres on how PT-141 10mg behaves at the level of cell-migration, proliferation and viability measurements. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

cAMP signalling pathways

Within cAMP signalling pathways, investigators use PT-141 10mg to probe signalling cross-talk between converging pathways. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Comparative MC receptor selectivity

Studies grouped under Comparative MC receptor selectivity generally treat PT-141 10mg as a tool for examining dose-dependent changes in cellular readouts. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Peptide stability and metabolism studies

In Peptide stability and metabolism studies, published work typically examines PT-141 10mg from the perspective of receptor occupancy and downstream second-messenger activity. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Reported Mechanism of Action

PT-141 activates melanocortin receptors with particular relevance to MC4R in hypothalamic circuits. MC4R signalling through Gs-coupled cAMP pathways is studied in relation to autonomic function and appetite regulation. Because the peptide is cyclic and carries a lactam bridge, its conformational rigidity and resistance to enzymatic breakdown are also frequently examined in comparative peptide pharmacology.

It is worth noting that mechanistic reports on PT-141 10mg come from several different model systems – cultured cells, tissue preparations and animal models – and that conclusions drawn in one system are not automatically transferable to another. The synthetic cyclic heptapeptide melanocortin receptor agonist classification describes the chemistry of the material, not a validated clinical action.

Purity, Testing and Certificates of Analysis

In peptide work, an impurity is not just a purity number on a page: co-eluting sequences, residual trifluoroacetate and moisture all alter how a preparation behaves in culture or in an assay. The certificate of analysis records the method used, the retention profile, the observed mass and the final purity figure, giving you a verifiable record rather than an unqualified purity claim.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Unreconstituted lyophilised powder should be stored at -20 degrees Celsius, protected from light and kept as dry as possible. After dissolution, store the preparation refrigerated at 2 to 8 degrees Celsius and aliquot it so that freeze-thaw cycling is avoided.

Reconstitution

For dissolution, start with bacteriostatic water. If the peptide is slow to enter solution, a preserved 0.9% benzyl alcohol solution can be used in its place.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 10mg vial dissolved in 2 mL of diluent gives approximately 5 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle PT-141 10mg in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

PT-141 10mg is supplied as a single 10mg vial priced at $55.

The vial range reflects the two common research patterns: small vials for titration and pilot work where only a little material is consumed per experiment, and larger vials for repeated runs that benefit from a single, internally consistent stock preparation.

How to Order PT-141 10mg Online

Orders placed before the daily cut-off are packed the same working day, and every shipment includes the batch-matched certificate of analysis. Browse the full Peptides > Melanotan Peptides category listing, or compare other compounds in the same family: Melanotan-2 (MT-2) 10mg, Melanotan-1 10mg, KPV 10mg.

Protide Health Lab supplies PT-141 10mg from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is PT-141 10mg?

PT-141 – bremelanotide – is a cyclic heptapeptide melanocortin receptor agonist related in structure to Melanotan-2 It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is PT-141 10mg supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of PT-141 10mg are available?

PT-141 10mg is supplied as a single 10mg vial.

How much does PT-141 10mg cost?

PT-141 10mg is priced at $55 per vial, and the batch certificate of analysis is included with the order.

What is PT-141 10mg supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should PT-141 10mg be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute PT-141 10mg?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is PT-141 10mg intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

If your study design calls for more than one compound, these related products are the ones most often purchased together with PT-141 10mg.

• Melanotan-2 (MT-2) 10mg – synthetic cyclic heptapeptide alpha-MSH analogue.
• Melanotan-1 10mg – synthetic tridecapeptide alpha-MSH analogue.
• KPV 10mg – synthetic tripeptide (Lys-Pro-Val), C-terminal fragment of alpha-MSH.
• VIP 10mg – endogenous 28-amino-acid neuropeptide (vasoactive intestinal peptide).

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 12052127)
• Peer-reviewed literature indexed in PubMed (PMID 11134297)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.