CJC-1295 (No-DAC) 10mg

Every laboratory purchase decision starts with the same questions – what exactly is in the vial, how pure is it, and can the supplier show the analytical paperwork? CJC-1295 (No-DAC) 10mg is supplied by Protide Health Lab as a lyophilised powder with a third-party high-performance liquid chromatography and mass spectrometry (HPLC-MS) purity report, and it is intended strictly for laboratory research use.

CJC-1295 without DAC – also written Mod GRF(1-29) – is a 29-amino-acid analogue of growth hormone-releasing hormone engineered with four substitutions (D-Ala2, Gln8, Ala15, Leu27) that make the peptide resistant to DPP-IV cleavage. The no-DAC version deliberately omits the drug-affinity-complex maleimide group that gives the DAC variant its long albumin-bound half-life, so it is used when a shorter, more pulsatile exposure profile is wanted in the study design. The freeze-dried presentation keeps the peptide in a form that tolerates shipping at ambient temperature while remaining suitable for long-term storage at reduced temperature once it reaches the laboratory.

CJC-1295 (No-DAC) 10mg Key Takeaways

• Compound class: synthetic 29-amino-acid growth hormone-releasing hormone analogue.
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 10mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price: $75 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is CJC-1295 (No-DAC) 10mg?
2. CJC-1295 (No-DAC) 10mg Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order CJC-1295 (No-DAC) 10mg Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is CJC-1295 (No-DAC) 10mg?

As a synthetic 29-amino-acid growth hormone-releasing hormone analogue, CJC-1295 (No-DAC) 10mg is offered by Protide Health Lab as a research reagent rather than as a therapeutic product. Analytical release testing covers sequence identity by mass spectrometry and purity by reverse-phase HPLC, and the outcome is documented in the certificate of analysis that accompanies the vial.

Also known as: CJC-1295 No DAC, Mod GRF(1-29), modified GRF 1-29, CJC-1295 without DAC.

Because the material is sold for laboratory investigation, Protide Health Lab does not make any claim about how it should be used, and every vial is labelled with the research-use-only designation. What can be verified before purchase is the analytical record: identity, purity, batch number and the testing laboratory.

CJC-1295 (No-DAC) 10mg Specifications

Property	Details
Product Contents	CJC-1295 (No DAC) 10mg Lyophilized Powder (99% purity) in 3mL vial.
Available Sizes	10mg
Peptide Type	Synthetic 29-amino-acid (GHRH) analogue
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 152 H 252 N 44 O 42
Molecular Weight	3367.90 g/mol
Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
CAS Number	863288-34-0
CID	91976842
Synonyms	CJC-1295 No DAC, CJC 1295, Mod GRF 1-29, Modified GRF(1-29)
Appearance	White to off-white lyophilized powder
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water

The table above summarises the identity and handling parameters of the material as supplied. Sequence, molecular weight and any database identifiers are given so that the vial can be reconciled with an existing internal specification or with a literature reference.

Research Overview: GHRH receptor signalling and cAMP assays

The research record for CJC-1295 (No-DAC) 10mg frames it as a synthetic 29-amino-acid growth hormone-releasing hormone analogue. Interest is concentrated in the following domains, each of which is presented here as a summary of published laboratory investigation only. If you are looking for buy cjc 1295 no dac online, compare the batch documentation rather than the headline purity figure: sequence identity, purity method and testing laboratory matter more than a single percentage.

GHRH receptor signalling and cAMP assays

Research interest in GHRH receptor signalling and cAMP assays centres on how CJC-1295 (No-DAC) 10mg behaves at the level of dose-dependent changes in cellular readouts. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Pulsatile growth hormone release models

Within Pulsatile growth hormone release models, investigators use CJC-1295 (No-DAC) 10mg to probe receptor occupancy and downstream second-messenger activity. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

DPP-IV stability and peptide half-life studies

Studies grouped under DPP-IV stability and peptide half-life studies generally treat CJC-1295 (No-DAC) 10mg as a tool for examining gene-expression shifts and protein-level endpoints. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Hypothalamic-pituitary axis research

In Hypothalamic-pituitary axis research, published work typically examines CJC-1295 (No-DAC) 10mg from the perspective of enzyme kinetics and substrate handling. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Comparative analogue pharmacology

Research interest in Comparative analogue pharmacology centres on how CJC-1295 (No-DAC) 10mg behaves at the level of cell-migration, proliferation and viability measurements. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Somatotropic cell culture endpoints

Within Somatotropic cell culture endpoints, investigators use CJC-1295 (No-DAC) 10mg to probe signalling cross-talk between converging pathways. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Reported Mechanism of Action

GHRH analogues act at the pituitary GHRH receptor, a class-B G-protein-coupled receptor that signals through cAMP and drives synthesis and release of growth hormone. The four substitutions in Mod GRF(1-29) increase enzymatic stability while preserving receptor affinity, and research compares the resulting pulse dynamics against native GHRH and against the DAC-modified analogue.

As with most research compounds, the mechanism described above is assembled from multiple published studies that used different concentrations, exposure times and model systems. Readers should treat it as a map of reported signalling behaviour for this synthetic 29-amino-acid growth hormone-releasing hormone analogue rather than as a definitive account of a single pathway.

Purity, Testing and Certificates of Analysis

The difference between a usable research reagent and a wasted experiment is often analytical – the presence of truncated sequences, deletion products or residual solvents can shift outcomes in ways that are hard to attribute after the fact. Each batch is accompanied by a certificate of analysis that reports the analytical method, the observed purity, the identity confirmation and the testing laboratory, so the data can be filed with your study records.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Before reconstitution, keep the vial frozen at -20 degrees Celsius, shielded from light, with the stopper in place and desiccant nearby if the laboratory is humid. A reconstituted solution is far less stable than the dry powder, so keep it refrigerated at 2 to 8 degrees Celsius and treat the working window as short.

Reconstitution

Most peptides in this catalogue dissolve readily in bacteriostatic water or in a 0.9% benzyl alcohol solution; a preserved diluent is often preferred when a multi-use vial will be drawn from repeatedly.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 10mg vial dissolved in 2 mL of diluent gives approximately 5 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle CJC-1295 (No-DAC) 10mg in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

CJC-1295 (No-DAC) 10mg is supplied as a single 10mg vial priced at $75.

Choosing a size is largely a question of how many separate preparations your protocol requires. Consolidating into one larger vial reduces handling steps and the associated risk of variability, while small vials keep unused material in the more stable dry state for longer.

How to Order CJC-1295 (No-DAC) 10mg Online

Domestic orders are processed promptly, packed discretely and shipped with tracking, with the certificate of analysis included for your records. Browse the full Peptides category listing, or compare other compounds in the same family: Sermorelin, Ipamorelin 10mg, CJC-1295 (No Dac) & Ipamorelin Blend.

Protide Health Lab supplies CJC-1295 (No-DAC) 10mg from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is CJC-1295 (No-DAC) 10mg?

CJC-1295 without DAC – also written Mod GRF(1-29) – is a 29-amino-acid analogue of growth hormone-releasing hormone engineered with four substitutions (D-Ala2, Gln8, Ala15, Leu27) that make the peptide resistant to DPP-IV cleavage It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is CJC-1295 (No-DAC) 10mg supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of CJC-1295 (No-DAC) 10mg are available?

CJC-1295 (No-DAC) 10mg is supplied as a single 10mg vial.

How much does CJC-1295 (No-DAC) 10mg cost?

CJC-1295 (No-DAC) 10mg is priced at $75 per vial, and the batch certificate of analysis is included with the order.

What is CJC-1295 (No-DAC) 10mg supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should CJC-1295 (No-DAC) 10mg be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute CJC-1295 (No-DAC) 10mg?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is CJC-1295 (No-DAC) 10mg intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

Researchers who work with CJC-1295 (No-DAC) 10mg frequently also examine the compounds below, either as alternatives within the same signalling family or as complementary reagents in a combined study design.

• Sermorelin – synthetic 29-amino-acid GHRH(1-29) amide.
• Ipamorelin 10mg – synthetic pentapeptide ghrelin receptor (GHS-R1a) agonist.
• CJC-1295 (No Dac) & Ipamorelin Blend – dual-peptide blend of Mod GRF(1-29) and the ghrelin receptor agonist Ipamorelin.
• Tesamorelin – synthetic 44-amino-acid GHRH analogue.

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 12094662)
• Peer-reviewed literature indexed in PubMed (PMID 10231762)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.