P21 10mg

Researchers looking to source P21 10mg in the United States usually need three things at once: verified purity, a documented third-party certificate of analysis and a vial that arrives intact. P21 10mg is supplied by Protide Health Lab as a lyophilised powder with a third-party high-performance liquid chromatography and mass spectrometry (HPLC-MS) purity report, and it is intended strictly for laboratory research use.

P21 is a tetrapeptide derived from residues 148-151 of ciliary neurotrophic factor (CNTF), with an adamantane moiety attached to its C-terminus. The adamantane group is intended to enhance metabolic stability and central nervous system exposure. P21 is classified as a CNTF mimetic because it reproduces a portion of the neurotrophic signalling of the parent cytokine without its full receptor-binding footprint. The freeze-dried presentation keeps the peptide in a form that tolerates shipping at ambient temperature while remaining suitable for long-term storage at reduced temperature once it reaches the laboratory.

P21 10mg Key Takeaways

• Compound class: synthetic CNTF-derived peptide mimetic (adamantane-modified tetrapeptide).
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 10mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price: $110 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is P21 10mg?
2. P21 10mg Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order P21 10mg Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is P21 10mg?

As a synthetic CNTF-derived peptide mimetic (adamantane-modified tetrapeptide), P21 10mg is offered by Protide Health Lab as a research reagent rather than as a therapeutic product. Analytical release testing covers sequence identity by mass spectrometry and purity by reverse-phase HPLC, and the outcome is documented in the certificate of analysis that accompanies the vial.

Also known as: P21, Peptide 21, P021, CNTF-derived tetrapeptide, Ac-DGGL-NH2 adamantane.

Because the material is sold for laboratory investigation, Protide Health Lab does not make any claim about how it should be used, and every vial is labelled with the research-use-only designation. What can be verified before purchase is the analytical record: identity, purity, batch number and the testing laboratory.

P21 10mg Specifications

Property	Details
Product Contents	P21 10mg Lyophilized Powder in 3mL vial.
Available Sizes	10mg
Peptide Type	Synthetic CNTF-derived peptide mimetic (adamantane-modified tetrapeptide)
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 27 H 42 N 6 O 8
Molecular Weight	578.66 g/mol
Sequence	Ac-Asp-Gly-Gly-Leu-NH 2 (C-terminal adamantane-modified, CNTF residues 148-151)
CAS Number	1246751-68-7
Appearance	White to off-white lyophilized powder in sealed glass vial
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water

The table above summarises the identity and handling parameters of the material as supplied. Sequence, molecular weight and any database identifiers are given so that the vial can be reconciled with an existing internal specification or with a literature reference.

Research Overview: BDNF expression and neurogenesis

The research record for P21 10mg frames it as a synthetic CNTF-derived peptide mimetic (adamantane-modified tetrapeptide). Interest is concentrated in the following domains, each of which is presented here as a summary of published laboratory investigation only. If you are looking for buy p21 peptide online, compare the batch documentation rather than the headline purity figure: sequence identity, purity method and testing laboratory matter more than a single percentage.

BDNF expression and neurogenesis

Research interest in BDNF expression and neurogenesis centres on how P21 10mg behaves at the level of dose-dependent changes in cellular readouts. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Hippocampal-dependent memory research

Within Hippocampal-dependent memory research, investigators use P21 10mg to probe receptor occupancy and downstream second-messenger activity. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Neuronal survival and differentiation

Studies grouped under Neuronal survival and differentiation generally treat P21 10mg as a tool for examining gene-expression shifts and protein-level endpoints. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Amyloid pathology models

In Amyloid pathology models, published work typically examines P21 10mg from the perspective of enzyme kinetics and substrate handling. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Cytokine-derived mimetic pharmacology

Research interest in Cytokine-derived mimetic pharmacology centres on how P21 10mg behaves at the level of cell-migration, proliferation and viability measurements. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Neurotrophic signalling pathways

Within Neurotrophic signalling pathways, investigators use P21 10mg to probe signalling cross-talk between converging pathways. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Reported Mechanism of Action

P21 is reported to increase BDNF expression in hippocampal tissue and to support neurogenesis in the dentate gyrus, effects attributed to its CNTF-derived sequence rather than to direct activation of the CNTF receptor complex. Published work links the peptide to improved performance in hippocampal-dependent memory tasks in animal models and to reduced amyloid-associated pathology in transgenic models.

As with most research compounds, the mechanism described above is assembled from multiple published studies that used different concentrations, exposure times and model systems. Readers should treat it as a map of reported signalling behaviour for this synthetic CNTF-derived peptide mimetic (adamantane-modified tetrapeptide) rather than as a definitive account of a single pathway.

Purity, Testing and Certificates of Analysis

The difference between a usable research reagent and a wasted experiment is often analytical – the presence of truncated sequences, deletion products or residual solvents can shift outcomes in ways that are hard to attribute after the fact. Each batch is accompanied by a certificate of analysis that reports the analytical method, the observed purity, the identity confirmation and the testing laboratory, so the data can be filed with your study records.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Before reconstitution, keep the vial frozen at -20 degrees Celsius, shielded from light, with the stopper in place and desiccant nearby if the laboratory is humid. A reconstituted solution is far less stable than the dry powder, so keep it refrigerated at 2 to 8 degrees Celsius and treat the working window as short.

Reconstitution

Most peptides in this catalogue dissolve readily in bacteriostatic water or in a 0.9% benzyl alcohol solution; a preserved diluent is often preferred when a multi-use vial will be drawn from repeatedly.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 10mg vial dissolved in 2 mL of diluent gives approximately 5 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle P21 10mg in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

P21 10mg is supplied as a single 10mg vial priced at $110.

Choosing a size is largely a question of how many separate preparations your protocol requires. Consolidating into one larger vial reduces handling steps and the associated risk of variability, while small vials keep unused material in the more stable dry state for longer.

How to Order P21 10mg Online

Domestic orders are processed promptly, packed discretely and shipped with tracking, with the certificate of analysis included for your records. Browse the full Peptides category listing, or compare other compounds in the same family: Adamax 10mg, Semax 10mg, Pinealon 20mg.

Protide Health Lab supplies P21 10mg from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is P21 10mg?

P21 is a tetrapeptide derived from residues 148-151 of ciliary neurotrophic factor (CNTF), with an adamantane moiety attached to its C-terminus It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is P21 10mg supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of P21 10mg are available?

P21 10mg is supplied as a single 10mg vial.

How much does P21 10mg cost?

P21 10mg is priced at $110 per vial, and the batch certificate of analysis is included with the order.

What is P21 10mg supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should P21 10mg be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute P21 10mg?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is P21 10mg intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

Researchers who work with P21 10mg frequently also examine the compounds below, either as alternatives within the same signalling family or as complementary reagents in a combined study design.

• Adamax 10mg – synthetic ACTH(4-7) analogue bearing an adamantylglycine residue.
• Semax 10mg – synthetic heptapeptide ACTH(4-7) analogue with Pro-Gly-Pro extension.
• Pinealon 20mg – synthetic tripeptide (Glu-Asp-Arg, pineal-derived sequence).
• Illumineuro “Einstein” Peptide Blend – four-peptide neuropeptide research blend.

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 23146997)
• Peer-reviewed literature indexed in PubMed (PMID 27112434)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.