GHK-Cu – Copper Peptide

A research-grade peptide is only as good as the chain of documentation behind it, from the synthesis batch record to the third-party purity report that ships with the vial. The GHK-Cu – Copper Peptide offered here is a lyophilised research powder, tested by an independent laboratory using HPLC-MS and released with a batch-matched purity report, so the analytical data you review belongs to the material in your vial.

GHK-Cu is the copper complex of the tripeptide Gly-His-Lys. The uncomplexed tripeptide, GHK, is a naturally occurring fragment of the alpha chain of collagen I, and it has a high affinity for copper(II). The metal complex is the form researchers generally use when they want to study copper-dependent extracellular matrix and regenerative signalling in a controlled aqueous system. Because the lyophilised format removes water from the preparation, the powder is stable during transport and can be stored frozen for extended periods before it is reconstituted for experimental work.

GHK-Cu – Copper Peptide Key Takeaways

• Compound class: copper(II)-binding tripeptide (Gly-His-Lys coordinated to copper).
• Format: lyophilised research powder in a sealed glass vial.
• Vial sizes: 50mg, 100mg.
• Purity: 99% (HPLC-MS verified, third-party tested).
• Price range: $55 to $65 per vial.
• Fulfilment: domestic US shipping with a batch certificate of analysis.
• Status: for laboratory research use only; not for human or veterinary use.

Table of Contents

1. What Is GHK-Cu – Copper Peptide?
2. GHK-Cu – Copper Peptide Specifications
3. Research Overview
4. Reported Mechanism of Action
5. Purity, Testing and Certificates of Analysis
6. Handling, Storage and Reconstitution
7. Available Sizes and Pricing
8. How to Order GHK-Cu – Copper Peptide Online
9. Frequently Asked Questions
10. Related Research Peptides
11. References and Further Reading

What Is GHK-Cu – Copper Peptide?

GHK-Cu – Copper Peptide is one of the copper(II)-binding tripeptide (Gly-His-Lys coordinated to copper) entries in the Protide Health Lab research catalogue. It is released for sale only after independent identity confirmation by mass spectrometry and purity measurement by HPLC, and the resulting report is stored against the batch number printed on the vial.

Also known as: GHK-Cu, Copper Peptide, Copper Tripeptide-1, Gly-His-Lys copper complex.

Nothing in this catalogue is presented as a treatment or a supplement. What the documentation does establish is that GHK-Cu – Copper Peptide is the sequence it claims to be, at the purity reported, in the vial that was shipped to you – which is the part of a peptide purchase that can actually be verified.

GHK-Cu – Copper Peptide Specifications

Property	Details
Product Contents	GHK-Cu Lyophilized Powder (99% purity) in 3mL vial.
Available Sizes	50mg, 100mg
Peptide Type	Copper(II)-binding tripeptide (3 amino acids, copper complex)
Purity	99% (HPLC-MS verified, third-party tested)
Molecular Formula	C 14 H 24 CuN 6 O 4
Molecular Weight	403.93 g/mol
Sequence	Gly-His-Lys
CAS Number	49557-75-7
CID	378611
Synonyms	GHK-Cu, GHK Cu, Copper Peptide, Copper Tripeptide-1, Gly-His-Lys:Cu(II)
Appearance	Blue to blue-violet lyophilized powder
Storage	Store at ≤6°C, sealed, away from heat, light, and moisture.
Solubility	Soluble in water

Reference values are provided for laboratory identification and comparison purposes. Where a molecular formula, sequence or identifier is listed, it reflects the compound as it is supplied and should be cross-checked against your own internal specification before use.

Research Overview: Fibroblast collagen and glycosaminoglycan synthesis

Published investigation of GHK-Cu – Copper Peptide treats it as a copper(II)-binding tripeptide (Gly-His-Lys coordinated to copper) and concentrates on mechanistic questions rather than clinical outcomes. The sections that follow summarise those areas so that a researcher can see where the compound has been studied. For anyone looking to buy ghk cu online, Protide Health Lab keeps the decision simple by attaching the analytical record for the specific batch to the product page and to the shipment.

Fibroblast collagen and glycosaminoglycan synthesis

Studies grouped under Fibroblast collagen and glycosaminoglycan synthesis generally treat GHK-Cu – Copper Peptide as a tool for examining gene-expression shifts and protein-level endpoints. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Extracellular matrix remodelling studies

In Extracellular matrix remodelling studies, published work typically examines GHK-Cu – Copper Peptide from the perspective of enzyme kinetics and substrate handling. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Copper delivery and lysyl oxidase cofactor research

Research interest in Copper delivery and lysyl oxidase cofactor research centres on how GHK-Cu – Copper Peptide behaves at the level of cell-migration, proliferation and viability measurements. The literature in this area is not uniform: study designs differ in concentration range, exposure time and model system, so comparisons across papers should be made with attention to those parameters. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Antioxidant gene-expression panels

Within Antioxidant gene-expression panels, investigators use GHK-Cu – Copper Peptide to probe signalling cross-talk between converging pathways. Endpoints here are typically quantitative – fluorescence, luminescence, chromatographic signal or imaging counts – which makes reproducible material quality a practical requirement rather than a formality. For a laboratory working in this field, the practical requirement is a peptide whose sequence identity and purity have been independently confirmed.

Hair follicle and dermal culture models

Studies grouped under Hair follicle and dermal culture models generally treat GHK-Cu – Copper Peptide as a tool for examining dose-dependent changes in cellular readouts. Because these endpoints are measured in controlled culture systems, results are usually reported against a vehicle control and a reference compound, which allows the contribution of the peptide itself to be separated from assay variability. This is one of the clearest reasons to insist on batch-level analytical documentation before designing an experiment.

Wound-repair and angiogenesis endpoints

In Wound-repair and angiogenesis endpoints, published work typically examines GHK-Cu – Copper Peptide from the perspective of receptor occupancy and downstream second-messenger activity. Reported findings in this area are most useful when the preparation is fully characterised, since an unquantified purity difference between batches can easily be mistaken for a biological effect. Reproducibility in this line of work depends heavily on the consistency of the starting material across repeats.

Reported Mechanism of Action

GHK-Cu is reported to influence collagen synthesis, glycosaminoglycan production and antioxidant defence, and to modulate the expression of a large set of genes in fibroblast culture. Copper delivered in this chelated form serves as a cofactor for lysyl oxidase, and the complex has also been linked to angiogenic signalling and to matrix metalloproteinase balance in remodelling tissue.

It is worth noting that mechanistic reports on GHK-Cu – Copper Peptide come from several different model systems – cultured cells, tissue preparations and animal models – and that conclusions drawn in one system are not automatically transferable to another. The copper(II)-binding tripeptide (Gly-His-Lys coordinated to copper) classification describes the chemistry of the material, not a validated clinical action.

Purity, Testing and Certificates of Analysis

In peptide work, an impurity is not just a purity number on a page: co-eluting sequences, residual trifluoroacetate and moisture all alter how a preparation behaves in culture or in an assay. The certificate of analysis records the method used, the retention profile, the observed mass and the final purity figure, giving you a verifiable record rather than an unqualified purity claim.

Independent analysis of this material reports 99% (HPLC-MS verified, third-party tested). The certificate of analysis records the method used, the chromatographic profile, the mass-spectrometric identity confirmation and the final purity value, and it is issued against the specific batch supplied. That distinction matters: an identity confirmation from mass spectrometry establishes that the principal peak corresponds to the expected molecular mass, while the chromatographic purity figure describes how much of the total peak area that principal peak represents. A third element of quality control, which is not visible on a purity number, is the water and salt content of the lyophilised powder – residual moisture and counter-ion content both change the effective concentration of the peptide when the vial is dissolved. If your protocol requires a specific acceptance threshold, verify it against the certificate of analysis for the batch you receive before beginning work, and file that document with your study records so the material can be traced later.

Handling, Storage and Reconstitution

Storing the lyophilised powder

Unreconstituted lyophilised powder should be stored at -20 degrees Celsius, protected from light and kept as dry as possible. After dissolution, store the preparation refrigerated at 2 to 8 degrees Celsius and aliquot it so that freeze-thaw cycling is avoided.

Reconstitution

For dissolution, start with bacteriostatic water. If the peptide is slow to enter solution, a preserved 0.9% benzyl alcohol solution can be used in its place.

To calculate a working concentration, divide the mass of peptide in the vial by the volume of diluent added. For example, a 50mg vial dissolved in 2 mL of diluent gives approximately 25 mg/mL per mL. A convenient shorthand is that a 10mg vial dissolved in 2mL of diluent gives a 5mg/mL stock, while the same vial dissolved in 5mL gives 2mg/mL. Add the diluent slowly down the wall of the vial rather than directing the stream onto the powder, swirl gently instead of shaking, and never vortex a peptide solution: mechanical shear and foaming both encourage aggregation.

Laboratory handling practice

Prepare and handle GHK-Cu – Copper Peptide in an appropriate laboratory environment using clean technique. Work with gloves and eye protection, use dedicated glassware or single-use labware, and label every aliquot with the compound name, concentration, batch number and preparation date. When drawing from a multi-use vial, swab the stopper before and after use and keep the needle small to reduce coreing. Avoid repeated freeze-thaw cycles, because each thaw exposes the peptide to a fresh round of hydrolysis and aggregation; prepare single-use aliquots instead. Dispose of all peptide waste in accordance with your institution’s chemical-waste policy, and record the batch number in your laboratory notebook so that any analytical outlier can be traced back to a specific vial.

Available Sizes and Pricing

Vial size	Price	Availability
50mg	$55	In stock
100mg	$65	In stock

The vial range reflects the two common research patterns: small vials for titration and pilot work where only a little material is consumed per experiment, and larger vials for repeated runs that benefit from a single, internally consistent stock preparation.

How to Order GHK-Cu – Copper Peptide Online

Orders placed before the daily cut-off are packed the same working day, and every shipment includes the batch-matched certificate of analysis. Browse the full Peptides > Copper Peptides category listing, or compare other compounds in the same family: AHK-Cu 100mg, GHK-Cu & KPV Blend, Glow Blend (GHK-CU, BPC-157, TB-500).

Protide Health Lab supplies GHK-Cu – Copper Peptide from domestic inventory with same-day dispatch for orders received before the daily cut-off. Each order includes the batch-matched certificate of analysis, and shipment tracking is provided so that delivery can be confirmed. Keep the vial closed until it reaches the laboratory, then store it as described in the handling section above.

Frequently Asked Questions

What is GHK-Cu – Copper Peptide?

GHK-Cu is the copper complex of the tripeptide Gly-His-Lys It is supplied as a research reagent for in-vitro laboratory investigation, not as a therapeutic product..

What purity is GHK-Cu – Copper Peptide supplied at?

The material is released against independent analytical testing, with a reported purity of 99% (HPLC-MS verified, third-party tested). The certificate of analysis for your specific batch records the method used, the chromatographic profile and the mass-spectrometric identity confirmation, and it ships with the order.

What vial sizes of GHK-Cu – Copper Peptide are available?

GHK-Cu – Copper Peptide is offered in 2 configurations: 50mg, 100mg. The larger sizes suit repeat runs that benefit from a single stock preparation, while smaller vials keep unused material in the stable lyophilised state for longer.

How much does GHK-Cu – Copper Peptide cost?

Pricing runs from $55 to $65 per vial depending on the size selected, and the current price for each configuration is listed in the sizes and pricing table above. The certificate of analysis is included at no additional cost.

What is GHK-Cu – Copper Peptide supplied as?

It is supplied as a lyophilised (freeze-dried) powder in a sealed glass vial. The dry format is the most stable way to ship and store a research peptide, and it keeps the material usable for longer than a pre-dissolved solution would.

How should GHK-Cu – Copper Peptide be stored?

Keep the sealed vial frozen at -20 degrees Celsius, protected from light, until you are ready to use it. After reconstitution, store the solution at 2 to 8 degrees Celsius and use single-use aliquots to avoid repeated freeze-thaw cycling, which accelerates hydrolysis and aggregation.

What diluent should be used to reconstitute GHK-Cu – Copper Peptide?

Bacteriostatic water is the usual choice; a preserved 0.9%% benzyl alcohol solution is a practical alternative when the same vial will be drawn from repeatedly. Add the diluent slowly down the vial wall, swirl gently and never vortex, because mechanical shear promotes aggregation. Divide the vial mass by the volume added to obtain your working concentration.

Is GHK-Cu – Copper Peptide intended for human use?

No. This product is a research chemical supplied for in-vitro laboratory investigation only. It is not intended for human or veterinary use, and it is not a treatment, diagnostic or supplement.

How can I confirm the certificate of analysis for my batch?

The certificate of analysis is matched to the batch number printed on the vial and is included with the shipment. Compare the reported purity and identity data against the acceptance criteria in your protocol and file the document with your study records so the material remains traceable.

Related Research Peptides

If your study design calls for more than one compound, these related products are the ones most often purchased together with GHK-Cu – Copper Peptide.

• AHK-Cu 100mg – synthetic copper tripeptide complex (Ala-His-Lys coordinated to copper(II)).
• GHK-Cu & KPV Blend – dual-peptide blend of the GHK-Cu complex and the alpha-MSH fragment KPV.
• Glow Blend (GHK-CU, BPC-157, TB-500) – three-peptide blend of GHK-Cu, BPC-157 and TB-500.
• Klow Blend (GHK-CU, KPV, BPC-157, TB-500) – four-peptide blend of GHK-Cu, KPV, BPC-157 and TB-500.

The complete research catalogue is available on the https://protidehealthlab.store/shop/ page. If you are unsure which vial size fits your protocol, order the smaller size first, confirm that the material meets your acceptance criteria against the certificate of analysis, and scale up once the preparation has performed as expected. Every listing shows the analytical documentation for the batch, so the material can be evaluated on evidence before it is ordered.

References and Further Reading

The links below point to publicly indexed literature and reference resources relevant to this compound class. They are provided so that the mechanistic summaries above can be traced to their sources. Access to full text depends on the subscription arrangements of your institution.

• Peer-reviewed literature indexed in PubMed (PMID 9967744)
• Peer-reviewed literature indexed in PubMed (PMID 1564192)
• PubMed – biomedical literature database maintained by the National Library of Medicine
• National Institutes of Health – public research and health information resources

Research Use Only Disclaimer

This product is sold strictly as a chemical reference material for in-vitro laboratory research and is not a drug, supplement, cosmetic or food. It must not be administered to humans or animals, must not be used for diagnostic or therapeutic purposes, and must be handled only by qualified personnel in an appropriate laboratory setting. Statements describing areas of scientific interest are summaries of published research literature and do not constitute claims of efficacy, safety or intended use. By purchasing, the buyer confirms that they are a qualified researcher and that the material will be used lawfully within an institutional or laboratory research context.